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Furthermore, the C-terminus of ECM1 can bind to the LG2 subdomain of the perlecan domain V, which is surrounded by EGF-like modules [40]

McCord et al., 2020

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Langman CB, Greenbaum LA, Grimm P, Sarwal M, Niaudet P, Deschenes G, Cornelissen EA, Morin D, Cochat P, Elenberg E, Hanna C, Gaillard S, Bagger MJ, Rioux P (2014) Quality of life is improved and kidney function preserved in patients with nephropathic cystinosis treated for 2 years with delayed-release cysteamine bitartrate

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It is essential to understand that these results are a "snapshot" in time