In this analysis of nearly 1,000 adults in their 60s and 70s followed for two years, participants who took a daily multivitamin (Centrum Silver) had statistically significantly slower increases in two epigenetic clocks compared to those taking a placebo
March 14, 2024
The study concluded that daily L-carnitine dosages, primarily at 2,000 mg, resulted in a modest, but statistically significant loss in body weight (mean loss 1.21 kg), BMI, and fat mass
No contraindications (e.g., personal/family history of medullary thyroid carcinoma or MEN2, pregnancy)
BPC-157 is a 15-residue, 1419.53 g/mol pentadecapeptide whose mechanistic literature centres on local angiogenic signalling, Hsieh and colleagues (J Mol Med, 2017) reported upregulation and internalisation of VEGFR2 in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reported increased FAK and paxillin phosphorylation with greater outgrowth and migration in cultured rat tendon fibroblasts
Laboratory protocols demonstrate that the peptide neutralizes doxorubicin-induced chemotoxicity and shows that research targeting of senescent cells is feasible even after health decline has occurred