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It is administered intranasally, which allows it to bypass the blood-brain barrier and act directly on central nervous system tissue
Compositional dynamics of the milk fat globule and its role in infant development
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Nevertheless, excessive PEGylation can introduce unintended consequences, including increased protein adsorption, which may alter the biodistribution and pharmacokinetics of the nanomaterials
To minimize such unwanted events, we developed a standardized thawing procedure for frozen samples, with a small sample volume (150-200 L): thawing under strict cooling conditions (+0C to +2C) within 12-15 minutes in an ice-water bath, without agitation