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This precise dynamic mechanism can be totally disrupted during cholesterol lithogenesis, since hepatic bile supersaturated with cholesterol delivers large amounts of solubilized cholesterol to the gallbladder epithelial cells

Jacqueline Maya, M.D., from Massachusetts General Hospital-Mass General Brigham in Boston, and colleagues conducted a retrospective cohort study of 149,790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025, to compare weight gain and pregnancy outcomes with and without exposure to GLP-1 RAs before or during early pregnancy

Patients with diagnosed diabetes should monitor glucose closely, as MOTS-cs insulin-sensitizing effects may potentiate hypoglycemia when combined with antidiabetic medications

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