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Think of GLP-1 as a messenger that tells your brain and digestive system when youve had enough food, said Dr

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In a 26-week study, tirzepatide was studied to determine its effect on biomarkers of nonalcoholic steatohepatitis (NASH) and fibrosis in patients with T2DM

For example, estrogen signaling has been shown to enhance the anorexigenic effects of GLP-1 RAs by modulating central pathways involved in food reward, which could account for the more pronounced weight loss observed in premenopausal women [49, 50]

Shed up to 20% of your weight

The extension data shows that weight loss at the 12mg dose continued to accumulate between week 80 and week 104 without an obvious plateau