Other Causes of Leg Cramps Its also important to know that leg cramps can be caused by many other things
In vivo , HJG shortened swim times in the Morris Water Maze and increased phosphorylated CREB levels in A-injected Wistar rats, demonstrating its neuroprotective potential (Kubota et al., 2017)
Further, there is a reduction in enteric serotonin concentration, attenuated intestinal motility, increased survival of cultured enteric neurons, the proliferation of cultured EGCs [119], and a particular effect on maintaining platelets function [128,129,130] (Table 2)
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Second, metabolic enzyme inhibitors, which are the COX-2 inhibitor nonsteroidal anti-inflammatory drugs used in clinical trials to treat patients with GA, can target specific AA metabolic pathways as well as alleviate inflammation during acute GA episodes
ROS is a known inducer of cell proliferation (73)