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J Diabetes (2019) 11(7):50918

ONC201 exerts p53-independent cytotoxicity through TRAIL and DR5 induction in mantle cell lymphomas

doi: 10.1002/ptr.2010

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The two therapies act on different axes and are generally well tolerated in combination when properly monitored

Overview IGF-DES is classified as a potent IGF-1 variant that appears to exhibit approximately 10-fold greater bioactivity than full-length IGF-1 in certain assays due to its reduced affinity for IGFBPs