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Ali SA, Gandhi R, Potla P, Keshavarzi S, Espin-Garcia O, Shestopaloff K, et al

PMCID: PMC5112015

In this study, NLRP3 inflammasome was activated in N9 murine microglia via 1 g/ml LPS (Lipopolysaccharide) for 4 h and 5 mM ATP (Adenosine 5-triphosphate) for 1 h, respectively

Advantages of molecular docking and dynamics simulations, X-ray crystallography, and cryo-electron microscopy have facilitated the discovery of allosteric sites to enhance our understanding of allosteric modulation

Its presence in the extracellular space also provides protection against inflammatory oxidants released by immune cells during immune responses

On the other hand, in terms of weight loss, available data suggest that the combination of the 2 agonists had a synergistic effect (table 1) [10]