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Its production can be triggered in two ways

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So, finally working on it, in a moderate, sustainable, reasonable way, is refreshing, honestly, with or without the drugs

doi: 10.1038/s41574-019-0176-8 2 LiuDZhangTWangYXiaL

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Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]