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The peptide promotes collagen synthesis, enhances blood flow to tendons, and improves biomechanical properties

A Phase I human safety study was completed but never published, and regulatory concerns about safety, purity, and administration routes have complicated further clinical research

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The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell

Pegylated arginine arginase (PEG-BCT-100) showed promising tumor suppressive activity, survival advantage, and safety against advanced HCC in phase I clinical trials of combination chemotherapy (oxaliplatin and capecitabine)

10.1016/j.ccmp.2024.100129 60 OyovwiM