These groups received intravenous treatments of PBS, oridonin, orid-liposome, orid-liposome-MAL, TLR2 pep-orid-liposome at a dose of 5 mg/kg, or PBS as control every other day
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Semaglutide has been in clinical use since 2017 for diabetes and since 2021 for weight management
These medications work by directly activating the GLP-1 receptor, amplifying the hormones effects
The mice received an intraperitoneal administration of isotonic saline (0.5 ml) to compensate for potential fluid loss
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