The fact that TRANSCEND produced peer-reviewed NEJM-level evidence for efficacy in this population with an 80% responder rate and a 20-percentage-point placebo-adjusted BMI swing signals that the rare disease field's investment in precision pharmacology for orphan conditions can yield results as striking as anything produced in the mass-market obesity space
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Yes, rapid initial weight loss often correlates with a greater initial metabolic shift, making the subsequent Metabolic Adaptation phase potentially more challenging to overcome effectively
ISR results from abnormal proliferation of vascular smooth muscle cells and excessive extracellular matrix synthesis within the stent, leading to re-narrowing of the coronary artery lumen and increasing the risk of recurrent ischemic events
Maintaining protein intake also becomes particularly important for individuals trying to lose body fat, as adequate protein may help support lean muscle mass when combined with resistance training
