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Statins, a widely known and used therapy that lowers LDL cholesterol does not reduce Lp(a) and has been shown to sometimes result in a slight increase

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Moonat, S., Starkman, B

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In the US, Wegovy, which has been specifically approved for weight loss by the FDA, carries a warning to professionals to monitor for suicidal thoughts and discontinue the medication if necessary

With the 2026 Standards of Care increasingly shifting the focus toward cardio-renal outcomes, many clinicians are asking: how far can we go safely with GLP1 receptor agonists in this population