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The total number of individuals with diabetes is projected to increase from 171 million in 2000 to 366 million by 2030 [104]

In the Iranian female population, the prevalence statistics were 20.6% for SUI, 10.4% for UUI, and 8.5% for MUI (Alizadeh et al

From a biological perspective, several mechanisms have been hypothesized through which modern glucose-lowering agents could influence VTE risk

Structural optimization: Further reduce IGFBP binding ability through site directed mutagenesis, or introduce transmembrane peptides to enhance tissue penetration

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This is possibly due to the immature antioxidant system and membrane repair mechanisms of the oocyte