At the end of the study, sciatic nerve nitrotyrosine and nitrite/nitrate concentrations were lower in the Metanx- treated ZDF rats compared with the untreated group
Xu, B., Yang, M., Li, Z., Zhang, Y., Jiang, Z., Guan, S., et al
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However, the rate at which these cytokines increased was not reported
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Clinical Indications for Higher IV Dosages For very severe cases, like serious neurological problems, higher doses of IV vitamin B12 might be needed