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The problem was the side effects associated, particularly with GLP-1, are what we call peak to trough: so the difference between the highest amount of drug and the lowest and then going back up again to the highest caused by this twice-a-day dosingwhich you can imagine someone bouncing around maybe two to three times, the drug at peak, then trough, causes a lot of GI distress
GLP-1 medications create a series of events: Your pancreas releases more insulin Glucagon (what triggers blood sugar release) is blocked Gastric emptying slows down (so you feel full longer) When you feel satisfied, youre less likely to overeat, and you may find it easier to stick with your daily calorie budget
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