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[1] These combined actions lead to improved glycemic control and significant weight reduction, with clinical trials in adults without diabetes demonstrating average weight loss of 15-22% of body weight over 72 weeks in the SURMOUNT-1 trial

Subsequently, these two groups independently reported that the synthetic GLP-1 peptide acted as a potent stimulator of insulin secretion in isolated perfused rat pancreas (24) and isolated perfused pig pancreas (23), respectively, thus implicating GLP-1 as the second incretin

(PubMed) Resseguie M, Song J, Niculescu MD, da Costa KA, Randall TA, Zeisel SH