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(2) Females of childbearing potential and female partners of male participants must be willing to use a highly effective method of contraception

de Lima et al., 2025)

However, despite improvements in OSA-related symptoms and hypertension, PAP has not demonstrated a benefit on composite cardiovascular endpoints in randomized controlled trials for primary [23] or secondary cardiovascular prevention [24,25,26]

The medication absorbs through the sublingual mucosa directly into the bloodstream, bypassing the digestive system