Having fast become established as a potentially life-changing treatment for Type 2 diabetes and obesity, emerging evidence of the cardio and neuroprotective effects of this category of medicines has only encouraged the application of a wonder drug label and questions regarding the limits of its potential
They work by slowing digestion, signaling fullness to the brain, and reducing hunger cues
Incretin-based therapies in the treatment of type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors
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Optimizing in vivo delivery and genome editing methods, including the use of DSB-free large DNA knock-in technologies like PASTE and dCas9-SSAP editor, could help bridge the gap between pre-clinical development and clinical translation 41,42,43,44,45,46
JAMA 315(1):3646