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Kidneys and plasma were collected 1 month after the end of DOX treatment from mice maintained under a standard 12 hour light/12 hour dark cycle with ad libitum feeding (sampled every 4 hours over a 24 hour cycle

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Likewise, humans with a naturally occurring mutation of proline-970 in the NPEY motif of the IR to threonine exhibit severe insulin resistance (18)

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Not advised to drink alcohol while using this medication