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there is no evidence of CV benefit with lixisenatide

The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive heart failure

Not directly, according to the article, because its effect on insulin secretion is glucose-dependent: insulin is released only when glucose is already elevated

Y en el caso de las personas sin antecedentes de trastorno por consumo de sustancias, los frmacos GLP-1 disminuan el riesgo de desarrollar uno con todas las principales sustancias adictivas (alcohol, opioides, cocana, cannabis y nicotina)

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After one month, the dose should be increased to a maintenance dose of 7 mg once daily