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Curr Med Res Opin (2007) 23(4):91931.10.1185/030079906X162746 118 StonehouseAHDarsowTMaggsDG

Abdominal pain and depression, not bowel habits, predict health care utilization in patients with functional bowel disorders

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PAMPs are recognized by pattern recognition receptors, such as lipopolysaccharide (LPS)-binding proteins and peptidoglycan recognition protein, and stimulate invertebrate immune responses (Ratcliffe et al

Possible triggers include ultraviolet (UV) light exposure, pregnancy, sex hormones, stress, thyroid disease, and some medications like birth control (contraceptive) pills and anti-seizure (phototoxic) medications