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The latter scenario points to the essential role of oxidant stress as an amplifying process of cell death signaling

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Similarly, impaired kidney function can slow clearance, potentially increasing exposure and side effect risk for the same nominal dose

Redox Biol 24:101218 Torresano L, Nuevo-Tapioles C, Santacatterina F, Cuezva JM (2020) Metabolic reprogramming and disease progression in cancer patients

A multidisciplinary committee discussed with the patient and his family the treatment plan, stating that his cancer was in stage IV according to the American Joint Committee on Cancer guidelines [11], including starting with chemotherapy followed by surgical excision, but he opted to proceed with the excision first because he could not tolerate the foul smell and severe pain and was concerned that he might develop an infection if he was left untreated