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Kamada, R., Toguchi, Y., Nomura, T., Imagawa, T

Upon nerve injury, SARM1 undergoes a conformational change that activates its NADase activity, leading to the rapid depletion of NAD + 232

Mfn2, a mitochondrial fusion protein, is phosphorylated by PINK1, which promotes the recruitment of Parkin to the outer mitochondrial membrane and initiates Parkin-dependent mitophagy (Twig et al., 2008)

Its levels can decline due to aging, toxins, inflammation, and oxidative damage

If that doesn't work, a controlled water bathnever exceeding 40C can provide the slight energy boost needed to get things moving