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We discovered that Diphenyleneiodonium chloride (DPI), an inhibitor of flavoprotein enzymes and mitochondrial complex I, synergizes with mitoquinone mesylate (MitoQ), a mitochondria-targeted antioxidant in 2D and 3D in vitro models of NB

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Therefore, intrinsic fluorescence-based studies are typically restricted to a limited number of aromatic residue-containing IDPs, which are usually characterized by surface location of Trp residues characterized by the red-shifted intrinsic fluorescence spectra with max at 340 353 nm (Permyakov and Uversky, 2010)