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doi: 10.1074/jbc.M111.310342 28 KosiborodMNAbildstrmSZBorlaugBAButlerJRasmussenSDaviesMet al

Furthermore, reduced sensitivity to AMPK activation with age or disease could result in reduced healthspan and lifespan (61)

Binding of GLP-1 to GLP1R has multiple effects, including enhancing insulin secretion from pancreatic beta cells in response to glucose, increasing insulin expression, preventing beta-cell apoptosis, promoting the formation of new beta cells, reducing glucagon secretion, slowing down stomach emptying, promoting satiety, and improving glucose disposal in peripheral tissues

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