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consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product
*Zepbound (tirzepatide) is FDA-approved for chronic weight management in adults with obesity or overweight who have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol
Cell Mol Life Sci 79:26
Type 2 diabetes impacts roughly half a billion people globally, and heart failure is one of its most common complications
Additionally, exenatide 4, a GLP-1R agonist, alleviated lipid-induced ER stress and improved hepatic steatosis in high-fat diet -fed mice via sirtuin 1 (SIRT1) 44