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When ERS occurs, the cells are able to maintain intracellular homeostasis through the unfolded protein response

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A decrease in the antioxidant capacity of the brain may have functional consequences through cell damage, chronic inflammation, protein, and DNA damage

Clinical trial data shows that participants in the STEP program saw the majority of their total weight loss occur in this window

Weeks 13-24: Optimization Phase This extended phase represents the sweet spot of the combined protocol

Furthermore, GIP has shown promise in improving determinants of nephropathy, such as diabetes and hypertension (Nagashima et al., 2011)