GIPR:GCGR co-agonism restores normal weight in obese rodents
Signal sensitivity pulsed dosing is the conservative way to avoid blunting the response over time
Common adverse reactions include gastrointestinal symptoms (which may lead to intestinal obstruction in severe cases), headache, migraine, dehydration, and erectile dysfunction
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Emerging evidence has suggested that obesogenic diets, including high-fat components, could alter GLP-1 production by affecting the gut microbiota [25,26,27,28,29]
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