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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
High concentrations of melatonin cause daytime sleepiness, dizziness, hypotonia, and low body temperature [6]
Arzneimittelforschung 62 (8), 355359
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