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Methods Study design and data source This was a Region-wide, retrospective, longitudinal, comparative effectiveness study

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Doctors and their patients can now consider this class of medications not only for the treatment of obesity and to control blood sugar, but also to benefit mens reproductive health. Implications for Clinical Practice The study underscores the broader systemic benefits of GLP-1-based therapies and other anti-obesity agents, particularly in populations at high risk of endocrine dysfunction

Second, we complement the meta-analysis using a systematic literature review, focusing on distinct reward phases and applications in clinical populations that may account for variability across studies

Because the experimental hypotheses and study results were a continuation of our previous project, data analysis was also performed based on this division