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Soluble fibre is particularly effective as gut bacteria ferment it into short-chain fatty acids that directly trigger GLP-1 release from intestinal L-cells

These results are in line with the findings of the large AWARD program, where both doses of 0.75 and 1.5 mg once-weekly induced HbA1c reduction between 0.7% and 1.6% as monotherapy or in combination (dual or triple therapy)

Serious but rare risks include pancreatitis, gallbladder disease, acute kidney injury secondary to dehydration, and hypersensitivity reactions

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Well-known drugs like semaglutide (Ozempic and Wegovy ) act on this pathway

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