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The chemistry of a person's gut microbiome, their proclivity toward addiction, or the molecular shape of their hormone receptors can all affect the drug's efficacy, she says

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Incretin therapy is used either with GLP-1 receptor agonists or with inhibitors of DPP-4, which is the enzyme that inactivates endogenously released GLP-1

6 Limitations and the Honest Bottom Line Pulling the threads together, the limitations bearing on the title question are specific and, importantly, they reinforce one another rather than sitting in isolation