The separated hexane layer was treated with carbon and silica gel and filtered over celite
In some cases, alternative treatments with fewer metabolic effects might be appropriate, or the timing of therapies could be optimised to minimise conflicting effects whilst maintaining therapeutic benefit
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Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains
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Scheer, S
