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The main limitation is that refrigerated storage does not fully halt degradation

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Vascular dysfunction: Characteristic changes in ferroptosis-related markers, including GPX4, FTH1, ACLS4, TFR1, and cyclooxygenase-2(COX-2), were detected in the retinal fibrovascular membranes of patients with proliferative diabetic retinopathy, cultured Human Retinal Microvascular Endothelial Cells (HRMECs), and the retinas of diabetic mice (99)

This increased macrophage-mediated acetylcholine (ACh) release facilitates the clearance of apoptotic neutrophils and enables the resolution of acute peritonitis (83)

Randolph M, Tosti A

Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart