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[PubMed] [Google Scholar] 97.Randle P.J., Garland P.B., Hales C.N., Newsholme E.A

Most gastrointestinal effects ease as the body adjusts over the first weeks

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Patients should be encouraged to work with physical therapists or exercise professionals to develop appropriate programs, particularly if they are deconditioned or have mobility limitations

However, the studys robustness was limited by small group sizes, incomplete statistical data on MapK and TNF-, and contradictory findings regarding gene expression differences (Daneshmand et al., 2016)

Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements