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Systemic administration data argue that the postsynaptic antagonistic effects of NTS1 on D2R function may predominate since brain-penetrating NT analogs given systemically reduce the pharmacological effects of psychostimulants and do not appear to be rewarding (Binder et al., 2005)

Interestingly, secretin receptor knockout mice maintain normal food intake and weight, suggesting that chronic absence of secretin signaling may not mirror the acute effects observed with pharmacological stimulation [39]

Psychoneuroendocrinology 164 , 107006

O., Silva, F., Gouveia-Fernandes, S

PubMed Sattar, N., McGuire, D.K., Pavo, I., Weerakkody, G.J., Nishiyama, H., Wiese, R.J., & Zoungas, S

She added that not everyone who drinks too much has substance use issues, but some do