This suggests that tesofensine may have two components: one anorexigenic and a second that stimulates energy expenditure, the latter perhaps mediated by its NE component [2, 61]
deficiency impairs redox balance, increases oxidative damage, and alters T3/T4 metabolism
Because Dihexa is both orally bioavailable and capable of crossing the blood-brain barrier, it can reach the central nervous system through routes that are practical for clinical use
It participates in the modulation of the activity and localization of numerous enzymes and receptors [147, 160, 161], takes part in the regulation of many physiological processes in the brain [147, 162], including synaptic plasticity [163, 164], axonal elongation, and neuronal survival [147, 165]
doi: 10.1016/j.intimp.2018.01.015 69 PengCShiQPLiuJYLvYJLiJYiLet al
Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, et al