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Thus, the interpretation of existing findings is challenging, and further research is required to better characterise bone responses to various IF schedules using well-controlled protocols of longer duration, adequately powered to assess changes in bone outcomes and designed to include clinically relevant bone assessments (BMD at the hip/lumbar spine, bone microstructure and fracture risk)

S., & Hecht, S

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The reason they cannot be compounded is regulatory, not scientific

This is especially relevant for tirzepatide dosing , where the escalation steps are larger and side effects at each new dose can be more pronounced