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Without sufficient B12, the body may produce abnormal red blood cells that dont function properly, leading to fatigue and weakness
The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly
Silverstein said he decided to investigate the over-prescribing of B12 shots, because "as an internal medicine resident, I have seen many patients come into the emergency department, and they were getting B12 injections without having a really good reason for it." His study could not determine why family physicians were prescribing it inappropriately including whether it was initiated by the doctor or at the request of the patient
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This is especially relevant if you: follow a restrictive diet, like a vegan diet are over the age of 60 are pregnant or nursing have a medical condition that can deplete B12 levels take a B12-depleting medication, like metformin or proton pump inhibitors In addition to learning about your symptoms and giving you a physical exam, a healthcare professional can rule out a B12 deficiency by ordering various blood tests( If youre diagnosed with too low B12 levels, your healthcare professional will recommend the most appropriate treatment
