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In animal models, including db/db mice, streptozotocin (STZ)-induced diabetic models, and non-obese diabetic (NOD) mice, renal tissues show increased iron content, elevated levels of MDA and ACSL4 , and reduced GPX4 expression, which are the signature features of ferroptosis (Wang et al., 2020

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Monocytes from PASC patients with ongoing fatigue show a sustained reduction of prostaglandin-generating enzyme, the cyclooxygenase 2 (COX-2) 219

KPV is a tripeptide lysine-proline-valine corresponding to the C-terminal three residues of -MSH

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[DOI] [PubMed] [Google Scholar] 154.Rhodes K., Braakhuis A