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Ipamorelin is prized for its selectivity: in preclinical work it stimulated GH with little effect on cortisol, prolactin, or aldosterone

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Even though L-carnitines central role is enhancing fatty acid oxidation, L-carnitine has been shown to have no influence on fat burning or fat loss when consumed alone

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10.2967/jnumed.106.032789 J

Despite promising preclinical studies, a 12-week clinical trial using an iteration of this initial dual-incretin agonist failed to demonstrate superiority relative to a GLP-1R monoagonist 15 , raising questions about multi-receptor strategies in humans