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An additional mode of communication from the gut to the brain includes the enteric nervous system (ENS) and sensory neurons expressing receptors to TNF-, IL-1 or IL-6 (243), and to 5-HT (244), which is abundantly produced at the gut level (245) (upwards black arrows in Figure 2 )

He discusses the nature of meaning and free will, arguing that individuals must create rather than search for purpose, and considers how mortality serves as a necessary boundary for civilization's progress

doi: 10.1038/s41423-019-0206-4 108 HannaJGoldman-WohlDHamaniYAvrahamIGreenfieldCNatanson-YaronSet al

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