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Because B12 is water-soluble, there is no toxicity

Key Takeaway: Clinical studies indicate that tirzepatide often leads to a measurable decrease in blood pressure as a result of significant weight loss

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Collectively, these findings suggest that integrating epitranscriptomic modulators with engineered biologics can coordinately dismantle both CSC-driven persistence and drug uptake/target loss barriers, thereby establishing a compelling framework for advancing MDR reversal strategies toward clinical application

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