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Sams VG, Blackledge C, Wijayatunga N, et al

Bariatric surgery itself increases endogenous GLP-1 levels, particularly after RYGB, contributing to improved glycemic control and weight loss

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PMID 34318734

A plausible explanation of this apparent dichotomy is that p53 promotes cell survival by preventing excessive increases in ROS under moderate oxidative stress, whereas when the oxygen species increase over a threshold level, it switches to becoming a ROS inducer, triggering cell death