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The K d values were determined based on thermophoresis-dependent signal changes, calculated by plotting normalized fluorescence (Fnorm) against ligand concentrations using MO

In this study, whole blood and intracellular exposures revealed pharmacokinetic profiles with a similar pattern

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Because the mouth has a rich blood and lymphatic supply, oral melanoma tends to spread early, about a third of patients have lymph node involvement at the time of diagnosis, and about a quarter have distant metastasis (spread of cancer cells to other parts of the body)

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