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The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

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Benefits of Retatrutide Therapy Unprecedented Weight Loss Early phase trials (NEJM 2023) showed average weight loss of ~24% at 48 weeks, which rivals bariatric surgery outcomes

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This risk is heightened when mixed with a GLP-1 medication, which already slows digestion and alters glucose response