Early detection and treatment prevent irreversible neurological complications
10.1073/pnas.0611680104 Proc
The MG-related metabolic pathway is being explored in the development of anti-cancer drugs, focusing on reducing MG stress or exploiting its cytotoxic effects to inhibit cancer progression
Small fibre polyneuropathy can result not only in neuropathic pain and other sensations such as pins and needles or itching but also, interestingly, in a very wide range of (familiar) autonomic symptoms including (but not restricted to) dry eyes, dry mouth, orthostatic dizziness, constipation, bladder incontinence, sexual dysfunction, trouble sweating etc (Tavee, Zhou, 2009)
Other therapeutic approaches targeting fibroblast ferroptosis have also emerged: the in vitro and in vivo experiments demonstrate that platelet-rich plasma (PRP) promotes healing of type 2 diabetic mouse ulcers by inhibiting fibroblast ferroptosis and improving functional impairment [78, 80], providing a new strategy for diabetic ulcer treatment
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