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Use of these medications on the index date was also an exclusion criterion, with the exception of treatment initiation with semaglutide or DPP4i on the index date in the corresponding study groups

Schulz KM, Pearson JN, Gasparrini ME, Brooks KF, Drake-Frazier C, Zajkowski ME, et al

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Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing

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