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Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac fibroblast proliferation and alpha-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway

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Research involving RETA allows investigators to examine: Comparative behaviour of single-, dual-, and triple-pathway signalling Pathway dominance and interaction effects Metabolic adaptability under multi-receptor stimulation System-level coordination rather than isolated receptor activation This makes RETA relevant to research focused on complex endocrine and metabolic system integration

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